Evans is still recovering from a foot problem while Betrand has been ruled out after testing positive for Covid-19 ahead of the win against Wolves.
But Timothy Castagne is available for Leicester after returning from an eye injury sustained for Belgium at EURO 2020.
James Maddison is also fit despite doubts over a back problem, while Jannik Vestergaard could make his first start for the club.
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Jamie Vardy scored Leicester's winner in their opening match against Wolves
West Ham v Leicester: Match stats and facts
West Ham completed a league double over Leicester last season; the Hammers are looking to record three consecutive Premier League wins over the Foxes for the first time since winning their first four in the competition against them between November 1994 and April 1997.
Leicester have kept a clean sheet in just 11% of their Premier League games against West Ham (3/28), only keeping a clean sheet in a lower percentage of games against Manchester United (7%) among teams they’ve faced at least 15 times in the division.
West Ham United won 10 home Premier League games in 2020-21, their highest tally in a top-flight season since 2001-02, when they won 12. However, the Hammers have lost their first home league match of the season in each of the last three campaigns, scoring once and conceding nine times in these matches.
Only Manchester City (45) and Manchester United (43) won more away points in the Premier League last season than Leicester City (38). However, they’ve only won their opening away Premier League match in four of their previous 15 seasons in the division, with two of those victories coming against West Ham in 2000-01 and 2015-16.
West Ham have won their last four Premier League matches on Monday and won five in total last season on that day, the most by a team in a Premier League season since Chelsea won five Monday games in 2016-17. Leicester, meanwhile, have won just one of their 14 away Premier League games on a Monday (D4 L9), a 4-1 win at Leeds United last November.
Leicester manager Brendan Rodgers has lost each of his last two Premier League games against David Moyes (both in 2020-21), as many defeats as he suffered against the Scottish manager in the competition in their first seven meetings (W3 D2 L2).
Since David Moyes returned for his second spell in charge of West Ham, his team have scored 94 goals in their 58 games in the Premier League. The only four teams to have netted more in this period - since January 2020 - are Manchester City, Manchester United, Liverpool and Chelsea.
Michail Antonio could become West Ham’s outright top scorer in the Premier League in this game, after drawing level with Paolo Di Canio with his goal last time out (47). Antonio has netted in each of his last two starts against Leicester in the competition, scoring once in each.
Leicester striker Kelechi Iheanacho has been involved in four goals in his last four Premier League appearances against West Ham (3 goals, 1 assist). Iheanacho has scored in his last three Premier League appearances in London, with no Foxes player ever scoring in four in a row in the capital in the competition (Gerry Taggart and Jamie Vardy also scored in three in a row).
Saïd Benrahma scored and assisted in West Ham’s victory over Newcastle on MD1; the first time he has done both in a Premier League game for the club. Since the start of last season, no West Ham player has made more assists from open play in the competition than Benrahma (7).